Ethical principles for medical research involving human subjects. To allow for a 10% drop-out rate, the total number of patients increased to 100. Learn, Weak ejaculation is where the force or amount of a persons ejaculation is less than usual. Flowchart showing participants and groups disposition. To establish that the product manufacturers addressed safety and efficacy standards, we: We do the research so you can find trusted products for your health and wellness. The secondary outcomes measured were semen parameters such sperm count, sperm concentration and progressive motility. Two patients dropped out in the first month and one in the third month. This site needs JavaScript to work properly. There might be no other obvious signs or symptoms. Get useful, helpful and relevant health + wellness information. Are You Unknowingly Lowering Your Sperm Count? https://www.uptodate.com/contents/search. the contents by NLM or the National Institutes of Health. No significant differences between two groups were observed in patients demographics or clinical characteristics (Table I). Accessibility Infertility is something many men experience. We include products we think are useful for our readers. You may be surprised to learn that ideal sperm conditions are slightly less than body temperature, which is why the testicles are positioned outside of the abdominal cavity. Carbohydrates (50-70%), lipids (3-8%), terpenes and phenolic compounds are the major constituents in ginger rhizomes. Oxidative Stress and Antioxidant Protection: The Science of Free Radical Biology and Disease. http://www.who.int/reproductivehealth/publications/infertility/9789241547789/en/. We compared a difference between baseline characteristics of patients after randomization into the 2 groups with a 2test for categorized data and with Students t test for continuous variables. 3. As a library, NLM provides access to scientific literature. Imaging tests of your reproductive organs, including. Problems can stop cells from growing into sperm. 2008 Jul 1;11(13):1723-7. doi: 10.3923/pjbs.2008.1723.1727. Genetic Damage in Human Spermatozoa. Emotional stress and inadequate sleep. The absence of glandular secretions reduces the overall volume of semen plasma and significantly increases sperm concentration in poultry. Urologic surgery. Accessed Aug. 8, 2018. Statistical tests were two tailed. Patients were eligible for enrolment of the study if they were aged more than 45 years old, had idiopathic infertility for more than 2 years, presence of fragmented DNA more than or equal to 15% of ejaculated spermatozoa, absence of leukocytospermia, alcohol or drug addiction, and occupational chemical exposure, not using warfarin or other anticoagulant, not using ginger or other herbal medicines and absence of systemic diseases. However, for the medical professional requesting or receiving the analysis, its really no different than a urine or blood sample, so theres no reason to feel awkward. Before and after treatment, standardized semen samples were obtained to determine sperm concentration, motility, and SDF according to World Health Organization. The effect of sperm DNA fragmentation on live birth rate after IVF or ICSI: a systematic review and meta-analysis. This procedure may involve your female partner taking a drug called clomiphene to support egg development. A novel antioxidant formulation designed to treat male infertility associated with oxidative stress: promising preclinical evidence from animal models. Muratori M, Tamburrino L, Marchiani S, Cambi M, Olivito B, Azzari C, et al. National Library of Medicine An increased level of DNA fragmentation may represent a cause of male infertility and lower natural conception, intrauterine insemination (IUI), and IVF outcome rates (6, 7). Objective: This study was designed to investigate the effects of ginger (Zingiber officinale) on sperm DNA fragmentation (SDF) in infertile men. Ali DA, Abdeen AM, Ismail MF, Mostafa MA. Aitken RJ, De Iuliis GN. Effect of Zingiber officinale (Ginger) on sodium arsenite-induced reproductive toxicity in male rats. What is safe? The first sign is mostly when you cant conceive when youre trying. The cause of the low volume of semen in poultry, compared with mammals, is the lack of sexual glands. Two slides were used for the negative (omitting the enzyme terminal transferase) and positive (using DNase I, 1mg/ml for 20 min at room temperature) controls (22). The authors declare that they have no conflict of interests. Average ejaculation frequency varies according to many factors, including a mans: According to the 2015 Sexual Exploration in America Study, partnered sex and the ejaculation that usually accompanies it is most frequent among men ages 2529, with 68.9% reporting vaginal intercourse during the last month. World Health Organization (WHO) (1999) consideration was used for clinical semen analysis (21). However, in a study conducted in 2012 by Al-Kadir Mares and Najam at the University of Tikrit, Iraq, a significant increase was observed in sperm count in infertile men after treatment with ginger. Trends of male factor infertility, an important cause of infertility: A review of literature. A range of medications may help treat premature ejaculation. After adjustment for aforementioned covariates, the difference remained significantly meaningful (mean difference: 3.21, 95%CI: 0.78-5.63, p=0.009). Low sperm count can be caused by a number of health issues and medical treatments. It is suggested that future clinical trials might look into larger, dose-response and longer therapy by ginger extracts. The average percentage of sperm DNA fragmentation (SDF) for two groups. Although its beneficial effect on fertility remains to be established, this finding opens avenues of future fertility research and treatment, and may affect public health. The figure drops slightly to 63.2%, among men in their 30s, and declines with each decade of advancing age. Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. Ginger Ginger may help increase testosterone levels and improve male fertility. (2017). Clipboard, Search History, and several other advanced features are temporarily unavailable. Low sperm count, also called oligospermia, is a major cause of male infertility. National Institute of Child Health and Human Development. Your sperm count is considered lower than normal if you have fewer than 15 million sperm per milliliter of semen. sharing sensitive information, make sure youre on a federal Three subjects in the placebo group discontinued treatment because of lost to follow-up. One medical definition is that you have fewer than 15 million sperm in 1 milliliter of semen. While frequent ejaculation may offer several health benefits, no evidence proves that never or infrequently ejaculating causes specific health issues. For cases involving large varicoceles, blockages, or issues with sperm leaving the body, surgery is an option. Secondary outcomes on bivariate and multivariate analysis, DNA fragmentation between two groups before and after treatment. Cigarette smoke contains more than 7000 chemicals and reactive oxygen species (ROS), which impair sperm function, decrease sperm count and ultimately lead to male infertility. Z. officinale crude plant material includes amino acids, raw fiber, ash, protein, phytosterols, vitamins (e.g., nicotinic acid and vitamin A) and minerals. Marijuana and opioids also reduce sperm production. You may have heard that masturbating too frequently can lower sperm count. Kumar N, et al. This study was designed to investigate the effects of ginger (Zingiber officinale) on sperm DNA fragmentation (SDF) in infertile men. Cleveland Clinic is a non-profit academic medical center. Besides being known as low sperm count, oligospermia is also called oligozoospermia. Is the ketogenic diet right for autoimmune conditions? {"type":"clinical-trial","attrs":{"text":"NCT02032251","term_id":"NCT02032251"}}NCT02032251. At the highest dose (13 mg/kg), sperm count and motility were fourfold less that that observed in controls. In bivariate analysis, DNA fragmentation was significantly lower in patients receiving ginger compared with placebo after three month of treatment (mean difference: 4.46, 95%CI: 2.04-6.88, p<0.001) (Figure 2). Sperm count is considered low if it dips below 15 million sperm. Considering normal circumstances, some conditions that can prevent spermatogenesis and decrease sperm quality and quantity include medication, chemotherapy, toxins, polluted air, lack of nutrients and vitamins, which are associated with adverse effects on spermatogenesis and sperm production. MNT is the registered trade mark of Healthline Media. Make your tax-deductible gift and be a part of the cutting-edge research and care that's changing medicine. 2023 Healthline Media LLC. Sperm quality isnt necessarily something you think about often. Sperm count is considered low if it dips below 15 million sperm per milliliter (mL) of semen, although the average is around 75 million sperm per mL. There are a variety of things that could cause you to experience oligospermia or other sperm disorders. Previously published data on the effects of antioxidants on sperm concentration, motility and morphology are contradictory. Although the effectiveness of ginger as an antioxidant agent has been exploited, little human research has been conducted on its activity on male reproductive functions. A systematic review of the effect of oral antioxidants on male infertility. In summary, there is solid evidence that ginger enhances semen quality and improves the main sperm parameters such as concentration, viability, motility and morphology. Related: Best home remedies for premature ejaculation. Learn about the causes, Nonsurgical and surgical options are available for foreskin restoration. According to Planned Parenthood, one cycle of IVF can cost $15,000 or more. World Medical Association Declaration of Helsinki. The present study has demonstrated that ginger in a controlled study of efficacy was effective in decreasing SDF in infertile men. The primary functions of the testes are to produce sperm (spermatogenesis) and to produce androgens, primarily testosterone (steroidogenesis). Hafez DA. It is also medically used for its immunomodulatory, anti-tumorigenic, anti-inflammatory, antiapoptotic and antioxidant properties (11). BMC Vet Res. Clinical trials and antioxidant outcomes. This oxidative stress-induced sperm damage has been proposed to be an influential contributing factor in more than half of all cases of male infertility (28). include protected health information. Protective effect of Zingiber officinale extract on rat testis after cyclophosphamide treatment. Myths exist about the dangers of regular masturbation. Those with a low or marginal sperm count should discuss ejaculation frequency with a knowledgeable doctor or reproductive endocrinologist. Exercise reduces the risk of cardiovascular disease. Philadelphia, Pa.: Elsevier 2017. https://www.clinicalkey.com. Most males ejaculate when having an orgasm, although some can have an orgasm without ejaculating. Diseases, including those related to genetics, infection, hormones and obstructions (blockages). Your doctor fertilizes the eggs in a lab and then transfers healthy embryos into the uterus to implant. It's the most common reversible cause of male infertility. That way, you can get a better picture of just how low your count might be, what treatments are available, and whether you want to explore options like IUI or IVF to grow your family. Researchers arent sure how many people have oligospermia. Couples can get pregnant with low sperm count. Infections in the reproductive tract can be treated with medications. The study medications were prepared in capsules of identical size and appearance and were packaged by the institute pharmacy according to a randomization list. Anabolic steroids, which are usually taken to increase muscle mass, will almost always shrink testicles and decrease sperm production. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This trial was designed to investigate the effects of ginger rhizome on sperm DNA fragmentation (SDF) and sperm parameters. All patients had given written informed consent before any study-related tests were done. The materials provided at this site are for educational and informational purposes only and are not intended for use as diagnosis or treatment of a health problem or as a substitute for consulting a licensed medical professional. The study did not establish that ejaculation could prevent cancer in younger men. Blockages that stop sperm from leaving your body. Youll likely be provided with a container at your doctors office. Increases blood flow. The cycle of the seminiferous epithelium in humans: A need to revisit? Prolonged or severe emotional stress may interfere with the hormones needed to produce sperm, while depression lowers sperm concentration. Also, there can be problems of abnormal sperm shape (morphology), movement (motility) or function. Sperm cell plasma membrane is also different from most of other cell membranes in lipid composition. The present study has demonstrated that ginger in a controlled study of efficacy was effective in decreasing SDF in infertile men. We'll take a look at fertility testing for men and what may (or may not) be contributing to the challenge of having a child. In contrast to the major impact on sperm DNA fragmentation, our findings did not show any significant improvement of sperm concentration, motility and morphology after in vivo ginger treatment. Others blame the heat generated from cell phones sitting in pants pockets. Ejaculation from partnered sex may be particularly beneficial because: Many men also find that ejaculation, whether alone or with a partner, helps them sleep. In a study conducted by Hafez in Greece on the effect of a ginger and cinnamon combination on infertile diabetic rats, a significant increase was observed in sperm parameters and reproductive behavior in terms of sperm parameters including count, motility and viability (15). This study required the enrollment of 45 patients in each group to have at least 80% power to detect effect size of 3 between treatment and placebo groups regard to main outcome (with two-sided test and type 1 error of 5%). They include: Infertility caused by low sperm count can be stressful for both you and your partner. Abad C, Amengual MJ, Goslvez J, Coward K, Hannaoui N, Benet J, et al. information highlighted below and resubmit the form. Before The average percentage of SDF for two groups is shown in Table II. Gonzalez-Marin C, Gosalvez J, Roy R. Types, causes, detection and repair of DNA fragmentation in animal and human sperm cells. Click here for an email preview. Approach to the Patient With Oligozoospermia, (https://academic.oup.com/jcem/article/98/3/873/2536497). If you have a low sperm count, there are certain things your healthcare provider may suggest that you do. You may increase your sperm count by stopping medications or behaviors that are contributing to low sperm levels. Sex may reduce the risk of cardiovascular disease. Henkel R, Kierspel E, Hajimohammad M, Stalf T, Hoogendijk C, Mehnert C, et al. Gholami-Ahangaran M, Karimi-Dehkordi M, Akbari Javar A, Haj Salehi M, Ostadpoor M. Vet Med Sci. In most cases of permanent ejaculation problems, sperm can still be retrieved directly from the testicles. In this procedure, doctors give the female partner certain drugs to develop healthy eggs and retrieve the mature eggs surgically.
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